The EU list of potential endocrine disruptors

The EU strategy for endocrine disruptors includes the task of compiling a candidate list of potential endocrine disruptors. The list prioritises the substances that must be evaluated further for endocrine disrupting effects.

The European Commission has prepared a strategy for endocrine disruptors. The short-, medium- and long-term aim of the strategy is to improve the environment and the health of the EU's citizens.

One of the initiatives of the strategy is to compile a list of potential endocrine disruptors. The list is based on the proposals of various organisations and countries for suspected endocrine disruptors.

The proposals were compared and a collective EU list of over 432 candidate substances established, which are to be studied further for endocrine-disrupting properties. In order to prioritise efforts, the substances have been subdivided into a number of categories:

  • Category 1: Substances for which endocrine activity have been documented in at least one study of a living organism. These substances are given the highest priority for further studies.
  • Category 2: Substances without sufficient evidence of endocrine activity, but with evidence of biological activity relating to endocrine disruption.
  • Category 3a and 3b: Substances for which there are no indications of endocrine-disrupting properties or which cannot be evaluated due to a lack of data.

The plan is to convert these lists into a dynamic working list, where substances can be added or removed as more evidence of their endocrine-disrupting properties becomes available.

Category 1

Category 1 contains 194 substances. This does not necessarily mean that there is final proof that the substance is an endocrine disruptor, but there is more or less comprehensive evidence of endocrine-disrupting effects in live animals. The substance should therefore be prioritised for further evaluation of endocrine disrupting properties.

Many of the substances in Category 1 have already been prohibited or are subject to restrictions (this applies to many biocides, for example). Some of the substances are covered by an authorisation scheme under which a risk assessment is performed of the substance’s use in a specific context (such as when used as a biocide, medication, cosmetic product, etc.)

All substances in Category 1 are included in the Danish Environmental Protection Agency's List of Undesirable Substances (LOUS) of 2010 if more than 100 tonnes of the substance are used annually in Denmark, unless they are already prohibited or are covered by an authorisation scheme.

The following table lists the names and CAS numbers of the 194 substances for which evidence of endocrine-disrupting properties has been found in a least one live organism.

Category 1 substances

CAS nr.Name

12789-03-6

 Chlordane

57-74-9

Chlordane, – cis- og trans-

143-50-0

Kepone (Chlordecone)

2385-85-5

 Mirex

8001-35-2

Toxaphene (Camphechlor)

50-29-3

DDT (technical) (Clofenotane)

50-29-3

 p,p’-DDT

3563-45-9

 Tetrachloro-DDT

50471-44-8

 Vinclozolin

12427-38-2

 Maneb

137-42-8

Metam Natrium

137-26-8

 Thiram

12122-67-7

 Zineb

58-89-9

Gamma-HCH (Lindane)

330-55-2

 Linuron

1912-24-9

 Atrazine

34256-82-1

 Acetochlor

15972-60-8

 Alachlor

100-42-5

 Styrene

118-74-1

Hexachlorobenzene ( HCB)

85-68-7

Butylbenzylphthalate ( BBP)

117-81-7

DEHP (Di-(2-ethylhexyl) phthalate)

84-74-2

DBP (Di-n-butylphthalate)

80-05-7

Bisphenol A(4,4’-isopropylidendiphenol)

1336-36-3

 PCB

35065-27-1

PCB 153

32774-16-6

PCB 169

2437-79-8

PCB 47

32598-13-3

PCB 77

53469-21-9

PCB Arochlor 1242

12672-29-6

PCB Arochlor 1248

11097-69-1

PCB Arochlor1254

11096-82-5

PCB Arochlor 1260 (clophen A60)

59536-65-1

PBBs = polybromerede biphenyler
(209 congenere)

40321-76-4

1,2,3,7,8 Pentachloro-dibenzodioxin
(1,2,3,7,8-PCDD)

1746-01-6

2,3,7,8-Tetrachloro-dibenzo-p-dioxin
( 2,3,7,8-TCDD)

107555-93-1

1,2,3,7,8-Pentabromo-dibenzofuran

No CAS

Tributyltin compounds

688-73-3

Tributyltin hydride

56-35-9

Tributyl Oxide (bis(tributyltin)oxide)

26354-18-7

Stannane, tributylmecrylate
(Stannane, tributylmethacrylate)
No CAS

Methoxyacrylate tributyltin copolymer

4342-30-7

 Phenol, 2-(tributylstannyl)oxy)carbonyl-

4342-36-3

 Stannane, benzoyloxytributyl-

4782-29-0

 Stannane, (1,2- phenylenebis (carbonyloxy))bis(tributyl-

36631-23-9

Stannane, tributyl(naphthalenyloxy)-
(Tributyltin naphtalate)

85409-17-2

Stannane, tributyl- , mono(naphthenoyloxy)-

24124-25-2

Stannane, tributyl (1-oxo-9,12-octadecadienyl)oxy)-

3090-35-5

Stannane, tributyl((1-oxo-9-octadecenyl)oxy)-

26239-64-5

Stannane, (1R-(1alpha,4abeta,4b alpha,10a alpha))-
Tributyl(((1,2,3,4,4a,4b,5,6,10,10a-decahydro-7-isopropyl-
1,4a-dimethyl-1-phenanthryl)carbonyl)oxy)-

1983-10-4

Stannane, tributylfluoro-

2155-70-6

Stannane, tributyl ((2-methyl-1-oxo-2-propenyl)oxy)-
No CAS

Tributyltincarboxylate

26636-32-8

Tributyltin naphthalate *
No CAS Tributyltinpolyethoxylate

2279-76-7

Tri-n-propyltin chloride (TPrT chloride)
Flere CAS-numre Triphenyltin

900-95-8

Fentin acetate

95-76-1

3,4-Dichloroaniline

108-46-3

 Resorcinol

61-82-5

Amitrol (Aminotriazol)

1836-75-5

 Nitrofen

140-66-9

4-tert-octylphenol

25154-52-3

Phenol, nonyl-

1461-25-2

Tetrabutyltin (TTBT)

99-99-0

4-Nitrotoluene

63-25-2

 Carbaryl

5103-73-1

Cis-Nonachlor

39765-80-5

Trans-Nonachlor

2971-22-4

1,1,1-trichloro-2,2-bis(4-chloro-phenyl)ethane

65148-80-3

3-MeO-o,p'-DDE

43216-70-2

3-OH-o,p'-DDT

65148-81-4

4-MeO-o,p'-DDE

65148-72-3

4-MeO-o,p'-DDT

65148-75-6

5-MeO-o,p'-DDD

65148-82-5

5-MeO-o,p'-DDE

65148-74-5

5-MeO-o,p'-DDT

65148-73-4

5-OH-o,p'-DDT

4329-12-8

m,p'-DDD

65148-83-6

o,p'-DDA-glycinat
(N-[(2-chlorophenyl)4-chlorophenyl)acetyl]glycin)

53-19-0

o,p'-DDD

3424-82-6

o,p'-DDE

14835-94-0

o,p'-DDMU

789-02-6

o,p'-DDT

72-54-8

p,p'-DDD

1022-22-6

p,p'-DDMU

72-55-9

p,p'-DDE

32809-16-8

 Procymidon

8018-01-7

 Mancozeb

9006-42-2

Metiram

(Metiram-complex

319-85-7

Beta-HCH

(isomer til gamma-HCH = Lindan)

608-73-1

Hexachlorocyclo-hexane

= HCH mixed (inkluderer gamma-HCH = Lindan)

1689-83-4

 Ioxynil

2971-36-0

1,1,1-trichloro-2,2-bis(4-Hydroxyphenyl)ethane

(HPTE)

30668-06-5

1,3-Dichloro-2,2-bis(4-methoxy-3- methylphenyl)propane

2971-36-0

Bis-OH-Methoxychlor

(1,1,1- trichloro-2,2-bis(4-hydroxyphenyl)ethane (HTPE))

72-43-5

 Methoxychlor

72-43-5

p,p'-Methoxychlor

122-14-5

 Fenitrothion

82657-04-3

Bifenthrin (@Talstar)

91465-08-6

Cyhalothrin, lambda-

52918-63-5

 Deltamethrin

10453-86-8

 Resmethrin

60168-88-9

 Fenarimol

1918-02-1

 Picloram

65277-42-1

 Ketoconazol

1087-64-9

 Metribuzin

86-50-0

Terbutryn

106-93-4

Ethylene Dibromid (1,2-dibromethan or EDB)

12002-48-1

Trichlorobenzene

608-93-5

 Pentachlorobenzene

87-86-5

Pentachlorophenol (PCP)

1806-26-4

4-octylphenol

11081-15-5

4-isooctylphenol

9016-45-9

 Nonylphenolethoxylat

85535-85-9

Intermediate chain chlorinated paraffins

85535-84-8

Short chain chlorinated paraffins

84-61-7

Dicyclohexyl phthalate (DCHP)

84-66-2

Diethyl phthalate (DEP)

101-53-1

Phenyl-4-hydroxy-phenylmethane
(4-Benzylphenol eller p-Benzylphenol)

25036-25-3

2,2'-bis(2-(2,3-epoxypropoxy) phenyl)propane
(2,2-BPPP) (isomer til BADGE)

106-89-8

Epichlorohydrin (3-Chloro-1,2-epoxypropane)

35693-92-6

2,4-6-Trichlorobiphenyl

53555-66-1

3,4',5-Trichlorobiphenyl

67651-37-0

3-Hydroxy-2',3',4',5'- tetrachlorobiphenyl

100702-98-5

4,4'-Dihydroxy-2,3,5,6-tetrachlorobiphenyl

13049-13-3

4,4'-Dihydroxy-3,3',5,5'-tetrachlorobiphenyl

67651-34-7

4-Hydroxy-2',3',4',5'-tetrachlorobiphenyl

14962-28-8

4-Hydroxy-2',4',6'-trichlorobiphenyl

53905-33-2

4-Hydroxy-2,2’, 5'-trichlorobiphenyl

111810-41-4

4-Hydroxy-3,3',4',5'-tetrachlorobiphenyl

4400-06-0

4-Hydroxy-3,4’, 5-trichlorobiphenyl

37680-73-2

4-OH-2,2',4',5,5'-pentachlorobiphenyl

54991-93-4

 Clophen A30

8068-44-8

Clophen A50

No CAS

Blanding af 2,3,4,5-Tetrachlorobiphenyl (PCB 61), 2,2’, 4,5,5'-Octachlorobiphenyl (PCB 101) og 2,2',3,3',4,4',5,5'-Octachlorobiphenyl (PCB 194)

56558-16-8

PCB 104(2,2',4,6,6'-Penta-chlorobiphenyl)

74472-37-0

PCB 114 (2,3,4,4',5-Penta-chlorobiphenyl)

76842-07-4

PCB 122 (2,3,3',4,5-Penta-chlorobiphenyl)

57465-28-8

PCB 126(3,3',4,4',5-Penta-chlorobiphenyl)

38380-07-3

PCB 128(2,2',3,3',4,4'-Hexachloro-biphenyl)

37680-65-2

PCB 18 (2,2',5-Tri-chlorobiphenyl)

55702-46-0

PCB 21 (2,3,4-Trichloro-biphenyl)

No CAS

PCB Aroclor 1016

32598-14-4

PCB 105 (2,3,3',4,4' -Penta-chlorobiphenyl)

7012-37-5

PCB 28 (2,4,4'-Tri-chlorobiphenyl)

35693-99-3

PCB 52 (2,2';5,5'-Tet ra-chlorobiphenyl)

35065-28-2

PCB 138(2,2',3,4,4',5'- Hexachlorobiphenyl)

35065-29-3

PCB180(2,2',3,4,4',5 ,5'- Heptachlorobiphenyl)

31508-00-6

PCB 118(2,3',4,4',5-Penta-chlorobiphenyl)

12642-23-8

 PCT Aroclor 5442

56614-97-2

3,9-Dihydroxy-benz(a)anthracene (3,9-DBA)

7099-43-6

5,6-Cyclopento-1,2-benzanthracene
(3,5-CPBA)

56-49-5

3-Methylcholanthrene (3-MC)

57-97-6

7,12-Dimethyl-1,2-benz(a)anthracene
(DMBA)

50-32-8

Benzo[a]pyrene (BAP)

50585-41-6

2,3,7,8-TeBDD
(tetrabrominated dibenzodioxin)

118174-38-2

 6-Methyl-1,3,8-trichloro-dibenzofuran

94-82-6

2,4-dichlorophenoxy-butyric acid ( 2,4-DB)

72-33-3

 Mestranol

10043-35-3

Boric Acid

104-40-5

Nonylphenol (4-NP)

1113-02-6

 Omethoate

1131-60-8

4-Cyclohexylphenol

120-47-8

Ethyl 4-hydroxybenzoate (Ethylparaben)

131-18-0

Di-n-pentylphthalate (DPP)

131-55-5

Benzophenone-2
( 2,2’,4,4’ tetra-hydroxybenzophenon)

131-56-6

2,4-Dihydroxybenzophenon
(Benzophenone-1)

131-70-4

Mono-n-butylphthalate

13593-03-8

Quinalphos (Chinalphos)

15087-24-8

3-Benzylidene camphor (3-BC)

1582-09-8

 Trifluralin

1634-04-4

Methyl-tert-butylether (MTBE)

25013-16-5

tert. Butylhydroxyanisol (BHA)

27193-28-8

Phenol, (1,1,3,3-tetramethylbutyl)-
(Octylphenol)

33204-76-1

2,6-cis-Diphenylhexamethyl-cyclotetrasiloxane

36861-47-9

3-(4-methyl-benzylidene)camphor

4376-20-9

Mono-2-ethylhexylphthalate (MEHP)

50-18-0

 Cyclophosphamide

611-99-4

4,4’-Dihydroxy-benzophenone

6164-98-3

Chlordimeform

7400-08-0

p-Coumaric acid (PCA)

77-09-8

3,3’Bis(4-hydroxyphenyl) phthalid
(Phenolphthaleine)

77-40-7

2,2-Bis(4-hydroxy-phenyl)-n-butan
(Bisphenol B)

92-69-3

4-Hydroxybiphenyl (4-Phenylphenol)

92-88-6

 4,4’Dihydroxy-biphenyl

94-13-3

n-Propyl p-hydroxybenzoate (Propylparaben)

94-26-8

n-Butyl p-hydroxybenzoate (Butylparaben)

96-12-8

Dibromochloropropane (DBCP)

96-45-7

 Ethylene Thiourea (ETU)

99-76-3

Methyl p-hydroxybenzoate (Methylparaben)

99-96-7

p-Hydroxybenzoic acid

____________
* The original report to the EU contained this CAS number, which the Danish Environmental Protection Agency has noted is erroneous. Tributyltin naphthalate is already listed under CAS no. 36631-23-9.